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KMID : 0604119960020020123
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Journal of the Korean Society of Menopause
1996 Volume.2 No. 2 p.123 ~ p.146
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Comparison of Biochemical Markers of Bone Turnover in Postmenopausal Women
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정호연/Chung, Ho Yeon
임창훈/김상우/한기옥/한인권/민헌기/Lim, Chang Hoon/Kim, Sang Woo/Han, ki Ok/Han, In Kwon/Min, Hun Ki
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Abstract
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To evaluate the clinical utility of recently developed biochemical markers in postmenopausal women, we compared the results of six assay for markers of bone formation, such as bone specific alkaline phopohatase & serum osteocalcin measured by RIA, ELISA(Novocalcin & N-mid terminal) and resorption, such as urinary deoxypyridinoline (Pyr links-D) and urinary degradation product of type I collagen peptides (CrossLaps). The intraassay coefficients of variation were less than 8% except Novocalcin (13.3%) and N-mid terminal osteocalcin (15%). Highly significant correlations were observed between turnover markers (r=0.625-0.953, p<0001) except N-mid terminal osteocalcin. Before we analyze correlation between BUD and turnover markers, we have to standardize patient´s BUD values among different dual X-ray aborptiometry (DEXA) scanners from three manufacturers. European spine phantom & patient for standardization for DEXA were evaluated on three system(DPX-L, XR36, QDR2000) and the linear regression equations calculated. Overall correlation between instruments were highly significant using phantom(r2=U95-0998) and patients (2=0.973-0318). In simple regression analysis, corrected spinal BUD using regression equation was significantly correlated with Novocalcin(r=0.38, p-0.01) and osteocalcin by RIA (r=0.4, P=0.01). But stepwise regression showed that YSM(years since menopause), Pyrilinks-D and N-mid terminal osteocalcin use of currently available biochemical markers of bone turnover shows that they nearly all have a role to play in diagnostic procedure. Combination of two to three markers determined at baseline in postmenopause women might predict bone loss.
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KEYWORD
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